Dysregulated balance of D- and L-amino acids modulating glutamatergic neurotransmission in severe spinal muscular atrophy

Dysregulated balance of D- and L-amino acids modulating glutamatergic neurotransmission in severe spinal muscular atrophy

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by reduced expression of the survival motor neuron (SMN) protein. In addition to motor neuron survival, SMN deficiency affects the integrity and function of afferent synapses that provide glutamatergic excitatory drive essential for mo...

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Main Authors: Amber Hassan, Raffaella di Vito, Tommaso Nuzzo, Matteo Vidali, Maria Jose Carlini, Shubhi Yadav, Hua Yang, Adele D'Amico, Xhesika Kolici, Valeria Valsecchi, Chiara Panicucci, Giuseppe Pignataro, Claudio Bruno, Enrico Bertini, Francesco Errico, Livio Pellizzoni, Alessandro Usiello
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Neurobiology of Disease
Subjects:
Spinal muscular atrophy
Cerebrospinal fluid
Nusinersen
Central nervous system
Glutamatergic neurotransmission
NMDA receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000658
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