A novel nanomedicine for osteosarcoma treatment: triggering ferroptosis through GSH depletion and inhibition for enhanced synergistic PDT/PTT therapy

A novel nanomedicine for osteosarcoma treatment: triggering ferroptosis through GSH depletion and inhibition for enhanced synergistic PDT/PTT therapy

Abstract Osteosarcoma treatment remains challenging due to the limitations of single-modality therapies. To address this, we designed a carrier-free nanomedicine SRF@CuSO4.5H2O@IR780 (CSIR) for synergistic ferroptosis, photodynamic therapy (PDT), and photothermal therapy (PTT) in osteosarcoma. Inter...

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Main Authors: Tangbing Xu, Qiming Ma, Chi Zhang, Xiaoyan He, Qian Wang, Yunfeng Wu, Kunpeng Qin, Faxue Liao, Ping Zhou, Pengfei Xu, Jialai Yang, Junjun Yang, Jun Chang, Lei Qiao, Yong Hu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Nanobiotechnology
Subjects:
Carrier-free nanomedicine
Osteosarcoma
Ferroptosis
PDT/PTT Therapy
Reactive oxygen species
Online Access:https://doi.org/10.1186/s12951-025-03380-4
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https://doi.org/10.1186/s12951-025-03380-4

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