Axon targeting of transcriptionally distinct pioneer neurons is regulated by retinoic acid signaling

Abstract During nervous system development, pioneer neurons (pioneers) extend their axons toward distant targets, creating a scaffold for follower neurons and defining the initial structure of the nervous system. Despite years of study, whether pioneer neurons are transcriptionally distinct from fol...

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Bibliographic Details
Main Authors: Benjamin M. Woodruff, Lauren N. Miller, Nicholas L. Calistri, Jacqueline R. McVay, Laura M. Heiser, Alex V. Nechiporuk
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61044-1
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