Deciphering the history of ERK activity from fixed-cell immunofluorescence measurements

Deciphering the history of ERK activity from fixed-cell immunofluorescence measurements

Abstract The RAS/ERK pathway plays a central role in diagnosis and therapy for many cancers. ERK activity is highly dynamic within individual cells and drives cell proliferation, metabolism, and other processes through effector proteins including c-Myc, c-Fos, Fra-1, and Egr-1. These proteins are se...

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Main Authors: Abhineet Ram, Michael Pargett, Yongin Choi, Devan Murphy, Carolyn Teragawa, Markhus Cabel, Nont Kosaisawe, Gerald Quon, John G. Albeck
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58348-7
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https://doi.org/10.1038/s41467-025-58348-7

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