Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses

Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses

Abstract Influenza B viruses are antigenically diverse and contribute significantly to the annual influenza burden. Here we report influenza B virus neutralizing single-domain antibodies that target highly conserved regions of the hemagglutinin and neuraminidase. Structural studies by single particl...

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Main Authors: Arne Matthys, Jan Felix, Joao Paulo Portela Catani, Kenny Roose, Wim Nerinckx, Benthe Van Buyten, Daria Fijalkowska, Nico Callewaert, Savvas N. Savvides, Xavier Saelens
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60232-3
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https://doi.org/10.1038/s41467-025-60232-3

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