AAV-regulated Serpine2 overexpression promotes hair cell regeneration

AAV-regulated Serpine2 overexpression promotes hair cell regeneration

Inner ear hair cell (HC) damage is irreversible in mammals, but it has been shown that supporting cells (SCs) have the potential to differentiate into HCs. Serpine2, a serine protease inhibitor, encodes protease nexin 1, and this has been suggested to be a factor that promotes HC regeneration. In th...

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Bibliographic Details
Main Authors: Qiuhan Sun, Fangzhi Tan, Xinlin Wang, Xingliang Gu, Xin Chen, Yicheng Lu, Nianci Li, Xiaoyun Qian, Yinyi Zhou, Ziyu Zhang, Man Wang, Liyan Zhang, Busheng Tong, Jieyu Qi, Renjie Chai
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
cochlea
hair cell regeneration
inner ear stem cell
Serpine2
AAV-ie
Online Access:http://www.sciencedirect.com/science/article/pii/S216225312400283X
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