An acute microglial metabolic response controls metabolism and improves memory

An acute microglial metabolic response controls metabolism and improves memory

Chronic high-fat feeding triggers metabolic dysfunction including obesity, insulin resistance, and diabetes. How high-fat intake first triggers these pathophysiological states remains unknown. Here, we identify an acute microglial metabolic response that rapidly translates intake of high-fat diet (H...

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Main Authors: Anne Drougard, Eric H Ma, Vanessa Wegert, Ryan Sheldon, Ilaria Panzeri, Naman Vatsa, Stefanos Apostle, Luca Fagnocchi, Judith Schaf, Klaus Gossens, Josephine Völker, Shengru Pang, Anna Bremser, Erez Dror, Francesca Giacona, Sagar Sagar, Michael X Henderson, Marco Prinz, Russell G Jones, John Andrew Pospisilik
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
microglia
metabolism
mitochondria
memory
diabetes
inflammation
Online Access:https://elifesciences.org/articles/87120
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https://elifesciences.org/articles/87120

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