Prognostic Significance of Microvessel Density and Hypoxic Markers in Canine Osteosarcoma: Insights into Angiogenesis and Tumor Aggressiveness

Prognostic Significance of Microvessel Density and Hypoxic Markers in Canine Osteosarcoma: Insights into Angiogenesis and Tumor Aggressiveness

Canine osteosarcoma (OSA) is an aggressive and highly malignant tumor of bone with a poor prognosis and it mirrors the disease in humans. Angiogenesis, the formation of new blood vessels, is driven by hypoxia-induced factors such as HIF-1α and VEGF, both of which play a crucial role in tumor growth...

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Bibliographic Details
Main Authors: Cecilia Gola, Marcella Massimini, Emanuela Morello, Lorella Maniscalco, Luiza Cesar Conti, Mariarita Romanucci, Matteo Olimpo, Leonardo Della Salda, Raffaella De Maria
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Animals
Subjects:
canine osteosarcoma
hypoxia
angiogenesis
microvessel density
immunohistochemistry
biomarkers
Online Access:https://www.mdpi.com/2076-2615/14/22/3181
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