Disruption of the novel nested gene Aff3ir mediates disturbed flow-induced atherosclerosis in mice

Disturbed shear stress-induced endothelial atherogenic responses are pivotal in the initiation and progression of atherosclerosis, contributing to the uneven distribution of atherosclerotic lesions. This study investigates the role of Aff3ir-ORF2, a novel nested gene variant, in disturbed flow-induc...

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Bibliographic Details
Main Authors: Shuo He, Lei Huang, Zhuozheng Chen, Ze Yuan, Yue Zhao, Lingfang Zeng, Yi Zhu, Jinlong He
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/103413
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