Maximum likelihood inference of time-scaled cell lineage trees with mixed-type missing data using LAML

Maximum likelihood inference of time-scaled cell lineage trees with mixed-type missing data using LAML

Abstract Dynamic lineage tracing technologies combine genome editing with single-cell sequencing to track cell divisions. We introduce Lineage Analysis via Maximum Likelihood (LAML) to infer a maximum likelihood time-resolved cell lineage tree under the Probabilistic Mixed-type Missing model, which...

Full description

Saved in:
Bibliographic Details
Main Authors: Gillian Chu, Uyen Mai, Henri Schmidt, Benjamin J. Raphael
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Genome Biology
Subjects:
Lineage tracing
Cell lineage
Phylogeny
Time-resolved
Maximum likelihood using LAML
Online Access:https://doi.org/10.1186/s13059-025-03649-9
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13059-025-03649-9

Similar Items