Prolyl‐isomerase Pin1 controls normal and cancer stem cells of the breast

Prolyl‐isomerase Pin1 controls normal and cancer stem cells of the breast

Abstract Mammary epithelial stem cells are fundamental to maintain tissue integrity. Cancer stem cells (CSCs) are implicated in both treatment resistance and disease relapse, and the molecular bases of their malignant properties are still poorly understood. Here we show that both normal stem cells a...

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Main Authors: Alessandra Rustighi, Alessandro Zannini, Luca Tiberi, Roberta Sommaggio, Silvano Piazza, Giovanni Sorrentino, Simona Nuzzo, Antonella Tuscano, Vincenzo Eterno, Federica Benvenuti, Libero Santarpia, Iannis Aifantis, Antonio Rosato, Silvio Bicciato, Alberto Zambelli, Giannino Del Sal
Format: Article
Language:English
Published: Springer Nature 2013-12-01
Series:EMBO Molecular Medicine
Subjects:
breast cancer
Fbxw7 E3 ubiquitin‐ligase
Notch
prolyl‐isomerase Pin1
stem cells
Online Access:https://doi.org/10.1002/emmm.201302909
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https://doi.org/10.1002/emmm.201302909

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