The SWELL1 Channel Promotes Ischemic Brain Damage by Mediating Neuronal Swelling and Glutamate Toxicity

The SWELL1 Channel Promotes Ischemic Brain Damage by Mediating Neuronal Swelling and Glutamate Toxicity

Abstract Cytotoxic neuronal swelling and glutamate excitotoxicity are two hallmarks of ischemic stroke. However, the underlying molecular mechanisms are not well understood. Here, it is reported that SWELL1, the essential subunit of the volume‐regulated anion channel (VRAC), plays a dual role in isc...

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Bibliographic Details
Main Authors: Jianan Chen, Junhua Yang, Jiachen Chu, Kevin Hong Chen, Jesse Alt, Rana Rais, Zhaozhu Qiu
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Advanced Science
Subjects:
cytotoxic neuronal swelling
dicumarol
glutamate excitotoxicity
ischemic stroke
SWELL1 channels
Online Access:https://doi.org/10.1002/advs.202401085
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https://doi.org/10.1002/advs.202401085

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