Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype

Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype

Abstract Macrophage plasticity is critical for maintaining immune function and developing solid tumors; however, the macrophage polarization mechanism remains incompletely understood. Our findings reveal that Mg2+ entry through distinct plasma membrane channels is critical to macrophage plasticity....

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Main Authors: Viviane Nascimento Da Conceicao, Yuyang Sun, Manigandan Venkatesan, Jorge De La Chapa, Karthik Ramachandran, Rahul S. Jasrotia, Victor Drel, Xiufang Chai, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00815-x
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https://doi.org/10.1038/s41698-025-00815-x

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