Establishment of a lupus-prone mouse model of pulmonary arterial hypertension with intermittent hypoxia: functional, biochemical and histological verifications

Establishment of a lupus-prone mouse model of pulmonary arterial hypertension with intermittent hypoxia: functional, biochemical and histological verifications

Pulmonary arterial hypertension (PAH) is one of the most severe complications of systemic lupus erythematosus (SLE) with high mortality and limited treatment options, primarily due to its unclear pathogenesis. This study aims to investigate the role of intermittent hypoxia (IH) in exacerbating pulmo...

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Bibliographic Details
Main Authors: Dengfeng Wu, Jiangbiao Xiong, Yiping Huang, Yue Yuan, Shunjia Xing, Rui Wu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Clinical and Experimental Hypertension
Subjects:
Pulmonary arterial hypertension
systemic lupus erythematosus
animal model
hypoxia
MRL/lpr mice
Online Access:https://www.tandfonline.com/doi/10.1080/10641963.2025.2500383
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https://www.tandfonline.com/doi/10.1080/10641963.2025.2500383

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