Increased Trypanocidal Activity of the Salinomycin Derivative Ironomycin Is Due to ROS Production and Iron Uptake Impairment

Increased Trypanocidal Activity of the Salinomycin Derivative Ironomycin Is Due to ROS Production and Iron Uptake Impairment

Salinomycin and its derivatives display promising anti-proliferating activity against bloodstream forms of <i>Trypanosoma brucei</i>. The mechanism of trypanocidal action of these compounds is due to their ionophoretic activity inducing an influx of sodium cations followed by osmotic wat...

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Bibliographic Details
Main Authors: Dietmar Steverding, Stuart A. Rushworth, Georgina R. Hurle, Michał Antoszczak, Michał Sulik, Adam Huczyński, Kevin M. Tyler
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
<i>Trypanosoma brucei</i>
ironomycin
salinomycin
trypanocidal activity
reactive oxygen species
Online Access:https://www.mdpi.com/1420-3049/29/23/5597
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