A Clinical and Pathological Variant of Acute Transplant Glomerulopathy
Acute transplant glomerulopathy transplant glomerulopathy (TG) is a common cause of late renal allograft loss. We describe a unique case of a renal transplant recipient who developed rapid-onset nephrotic-range proteinuria and acute kidney injury secondary to C4d negative acute TG. Two courses of in...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2014/961987 |
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| author | Miklos Z. Molnar G. V. Ramesh Prasad Darren A. Yuen Serge Jothy Jeffrey S. Zaltzman |
| author_facet | Miklos Z. Molnar G. V. Ramesh Prasad Darren A. Yuen Serge Jothy Jeffrey S. Zaltzman |
| author_sort | Miklos Z. Molnar |
| collection | DOAJ |
| description | Acute transplant glomerulopathy transplant glomerulopathy (TG) is a common cause of late renal allograft loss. We describe a unique case of a renal transplant recipient who developed rapid-onset nephrotic-range proteinuria and acute kidney injury secondary to C4d negative acute TG. Two courses of intravenous Rituximab resulted in significant improvement in proteinuria and allograft function. In the setting of acute nephrotic-range proteinuria postrenal allograft, both renal biopsy with electron microscopy and screening for de novo donor-specific antibody should be performed to distinguish atypical presentations of TG from other diagnoses. |
| format | Article |
| id | doaj-art-b0229c8fb6eb48d6abce02064c0b616b |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-b0229c8fb6eb48d6abce02064c0b616b2025-02-03T07:26:15ZengWileyCase Reports in Pathology2090-67812090-679X2014-01-01201410.1155/2014/961987961987A Clinical and Pathological Variant of Acute Transplant GlomerulopathyMiklos Z. Molnar0G. V. Ramesh Prasad1Darren A. Yuen2Serge Jothy3Jeffrey S. Zaltzman4Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38152, USARenal Transplant Program, St. Michael’s Hospital, University of Toronto, Toronto, ON, M5B 1W8, CanadaRenal Transplant Program, St. Michael’s Hospital, University of Toronto, Toronto, ON, M5B 1W8, CanadaDepartment of Laboratory Medicine, St. Michael’s Hospital and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S 1A1, CanadaRenal Transplant Program, St. Michael’s Hospital, University of Toronto, Toronto, ON, M5B 1W8, CanadaAcute transplant glomerulopathy transplant glomerulopathy (TG) is a common cause of late renal allograft loss. We describe a unique case of a renal transplant recipient who developed rapid-onset nephrotic-range proteinuria and acute kidney injury secondary to C4d negative acute TG. Two courses of intravenous Rituximab resulted in significant improvement in proteinuria and allograft function. In the setting of acute nephrotic-range proteinuria postrenal allograft, both renal biopsy with electron microscopy and screening for de novo donor-specific antibody should be performed to distinguish atypical presentations of TG from other diagnoses.http://dx.doi.org/10.1155/2014/961987 |
| spellingShingle | Miklos Z. Molnar G. V. Ramesh Prasad Darren A. Yuen Serge Jothy Jeffrey S. Zaltzman A Clinical and Pathological Variant of Acute Transplant Glomerulopathy Case Reports in Pathology |
| title | A Clinical and Pathological Variant of Acute Transplant Glomerulopathy |
| title_full | A Clinical and Pathological Variant of Acute Transplant Glomerulopathy |
| title_fullStr | A Clinical and Pathological Variant of Acute Transplant Glomerulopathy |
| title_full_unstemmed | A Clinical and Pathological Variant of Acute Transplant Glomerulopathy |
| title_short | A Clinical and Pathological Variant of Acute Transplant Glomerulopathy |
| title_sort | clinical and pathological variant of acute transplant glomerulopathy |
| url | http://dx.doi.org/10.1155/2014/961987 |
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