Causal effects of brain subregion gene expression on inflammatory bowel diseases revealed by Mendelian randomization and single cell analysis

Causal effects of brain subregion gene expression on inflammatory bowel diseases revealed by Mendelian randomization and single cell analysis

Abstract Inflammatory Bowel Diseases (IBDs), including Ulcerative Colitis (UC) and Crohn’s Disease (CD), are chronic gastrointestinal disorders. The gut–brain axis integrates various signals, but its impact on IBD is unclear. Using Mendelian Randomization, we evaluated causal relationships between 1...

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Bibliographic Details
Main Authors: Yuan Li, Yao Wang, Simeng Chen, Lijia Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Inflammatory bowel disease
Crohn’s disease
eQTL
Brain-gut axis
Summary Data-based Mendelian randomization
Single-cell RNA sequencing
Online Access:https://doi.org/10.1038/s41598-025-08633-8
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https://doi.org/10.1038/s41598-025-08633-8

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