Plasma Metabolic Outliers Identified in Estonian Human Knockouts

Plasma Metabolic Outliers Identified in Estonian Human Knockouts

<b>Background/Objectives:</b> Metabolomics, in combination with genetic data, is a powerful approach to study the biochemical consequences of genetic variation. We assessed the impact of human gene knockouts (KOs) on the metabolite levels of Estonia Biobank (EstBB) participants and integ...

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Bibliographic Details
Main Authors: Ketian Yu, Estonian Biobank Research Team, Karol Estrada, Tõnu Esko, Mart Kals, Tiit Nikopensius, Jaanika Kronberg, Urmo Võsa, Arthur Wuster, Lorenzo Bomba
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Metabolites
Subjects:
human knockouts
metabolomics
predicted loss of function
pyrimidine pathway
pharmacogenomics
drug development
Online Access:https://www.mdpi.com/2218-1989/15/5/323
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