Comparative analysis of whole-genome sequencing of tumor and cfDNA in a neuroblastoma patient: a case report

Comparative analysis of whole-genome sequencing of tumor and cfDNA in a neuroblastoma patient: a case report

High-risk neuroblastoma (NB) poses significant challenges in pediatric oncology due to its resistance to conventional therapies, leading to relapse and poor prognosis. Copy number variations (CNVs) are strong prognostic factors in NB, prompting exploration into alternative methods for CNV profiling....

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Bibliographic Details
Main Authors: Susanne Fransson, Kleopatra Georgantzi, Anna Djos, Jennie Gaarder, Johanna Svensson, Vimala Anthonydhason, Per Kogner, Tommy Martinsson, Ganesh Umapathy
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
circulating cell free DNA (cfDNA)
whole genome sequencing (WGS)
MET (c-MET)
liquid biopsy
neuroblastoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1569520/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1569520/full

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