Administration of a Selective Antagonist for Pituitary Adenylate Cyclase‐Activating Polypeptide Receptor in the Hippocampus Causes Anxiolytic Effects in the Male Rat

Administration of a Selective Antagonist for Pituitary Adenylate Cyclase‐Activating Polypeptide Receptor in the Hippocampus Causes Anxiolytic Effects in the Male Rat

ABSTRACT Pituitary adenylate cyclase‐activating polypeptide (PACAP) affects rodents' stress‐related behaviors, such as anxiety‐like behavior or fear conditioning. However, previous studies have investigated the effect of intracerebroventricular, but not hippocampal, injection of this PAC1R‐sele...

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Bibliographic Details
Main Authors: Kaito Sato, Shuichi Chiba, Taichi Hatakeyama, Takashi Matsuwaki, Gen Watanabe, Maiko Kawaguchi
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Neuropsychopharmacology Reports
Subjects:
anxiety
elevated plus‐maze test
hippocampus
pituitary adenylate cyclase‐activating polypeptide
Sprague–Dawley rat
Online Access:https://doi.org/10.1002/npr2.12514
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https://doi.org/10.1002/npr2.12514

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