Single-cell RNA sequencing via endoscopic ultrasound-guided fine-needle biopsy for pancreatic tumors uncovered an aggressive subclone with a poor prognosis

Single-cell RNA sequencing via endoscopic ultrasound-guided fine-needle biopsy for pancreatic tumors uncovered an aggressive subclone with a poor prognosis

Background: Single-cell RNA sequencing (scRNA-seq) is a powerful tool which can unveil regulatory connections between genes and cells. However, due to the high demand for tissue quality, most scRNA-seq for pancreatic cancer is carried out by surgical specimen. This study (NCT05767697) aims to gain p...

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Bibliographic Details
Main Authors: Y.-Y. Su, M.-Y. Lin, S.M. Cheng, W.-L. Chang, C.-W. Hsu, C.-M. Yeh, C.-C. Yu, Y.-C. Hou, C.-J. Huang, Y.-S. Liu, Y.-J. Chao, D.-Y. Hwang, Y.S. Shan, L.-T. Chen
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:ESMO Gastrointestinal Oncology
Subjects:
pancreatic cancer
transcriptome analysis
tumor heterogeneity
UBE2C
Online Access:http://www.sciencedirect.com/science/article/pii/S2949819824000748
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