Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

Abstract Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are associated with impairment of intestinal epithelial barrier. Here, we investigated the role of matrix metalloproteinase MMP13 in these diseases. We observed that MMP13−/− mice display a strong protectio...

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Main Authors: Roosmarijn E. Vandenbroucke, Eline Dejonckheere, Filip Van Hauwermeiren, Sofie Lodens, Riet De Rycke, Elien Van Wonterghem, An Staes, Kris Gevaert, Carlos López‐Otin, Claude Libert
Format: Article
Language:English
Published: Springer Nature 2013-05-01
Series:EMBO Molecular Medicine
Subjects:
IBD
intestinal permeability
matrix metalloproteinase
sepsis
tumour necrosis factor
Online Access:https://doi.org/10.1002/emmm.201202100
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https://doi.org/10.1002/emmm.201202100

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