Synthesis and Characterization of Novel Co(III)/Ru(II) Heterobimetallic Complexes as Hypoxia-Activated Iron-Sequestering Anticancer Prodrugs

Synthesis and Characterization of Novel Co(III)/Ru(II) Heterobimetallic Complexes as Hypoxia-Activated Iron-Sequestering Anticancer Prodrugs

Heterobimetallic complexes of an ambidentate deferiprone derivative, 3-hydroxy-2-methyl-1-(3-((pyridin-2-ylmethyl)amino)propyl)pyridin-4(1H)-one (PyPropHpH), incorporating an octahedral [Co(4N)]<sup>3+</sup> (4N = tris(2-aminoethyl)amine (tren) or tris(2-pyridylmethyl)amine (tpa)) and a...

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Bibliographic Details
Main Authors: Tan Ba Tran, Éva Sipos, Attila Csaba Bényei, Sándor Nagy, István Lekli, Péter Buglyó
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
organometallic complexes
hypoxia-activated prodrugs
iron chelators
anticancer
Online Access:https://www.mdpi.com/1420-3049/29/24/5967
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