L-Kynurenine participates in cancer immune evasion by downregulating hypoxic signaling in T lymphocytes

L-Kynurenine participates in cancer immune evasion by downregulating hypoxic signaling in T lymphocytes

Malignant tumors often escape anticancer immune surveillance by suppressing the cytotoxic functions of T lymphocytes. While many of these immune evasion networks include checkpoint proteins, small molecular weight compounds, such as the amino acid L-kynurenine (LKU), could also substantially contrib...

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Bibliographic Details
Main Authors: Stephanie Schlichtner, Inna M. Yasinska, Elena Klenova, Maryam Abooali, Gurprit S. Lall, Steffen M. Berger, Sabrina Ruggiero, Dietmar Cholewa, Milan Milošević, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
cancer
immune checkpoints
immune escape
kynurenine
T cells
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2244330
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https://www.tandfonline.com/doi/10.1080/2162402X.2023.2244330

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