Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective TIM-3 inhibitor for NSCLC immunotherapy

Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective TIM-3 inhibitor for NSCLC immunotherapy

Non-small cell lung cancer (NSCLC) remains a significant clinical challenge, necessitating exploration of novel therapeutic targets such as TIM-3. In this study, integrated computational and experimental methods were utilized to identify potent TIM-3 inhibitors. Survival analysis revealed a signific...

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Bibliographic Details
Main Authors: Xinxin Ying, Yangyong Lou, Yueming Wu, Weiwei Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Chemistry
Subjects:
TIM-3
NSCLC
HIT104310526
survival analysis
molecular dynamics
experimental validation
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1622511/full
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https://www.frontiersin.org/articles/10.3389/fchem.2025.1622511/full

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