Copper supplementation mitigates Parkinson-like wild-type SOD1 pathology and nigrostriatal degeneration in a novel mouse model

Copper supplementation mitigates Parkinson-like wild-type SOD1 pathology and nigrostriatal degeneration in a novel mouse model

Abstract Misfolded wild-type superoxide dismutase 1 (disSOD1) protein is implicated in the death of substantia nigra (SN) dopamine neurons in Parkinson disease. Regionally reduced copper availability, and subsequent reduced copper binding to SOD1, is a key factor driving the development of this path...

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Main Authors: Benjamin D. Rowlands, Benjamin G. Trist, Connor Karozis, Greta Schaffer, David Mor, Richard Harwood, Sarah A. Rosolen, Veronica Cottam, Freyja Persson-Carboni, Miriam Richardson, Anne A. Li, Michael P. Gotsbacher, Amr H. Abdeen, Rachel Codd, Kay L. Double
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Acta Neuropathologica Communications
Subjects:
Neurodegeneration
Superoxide dismutase 1
Post-translational modification
Protein misfolding
Parkinson disease
CuATSM
Online Access:https://doi.org/10.1186/s40478-025-02048-2
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https://doi.org/10.1186/s40478-025-02048-2

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