EXOGENOUS AND ENDOGENOUS FACTORS IN ATHEROSCLEROSIS PATHOGENESIS. RECEPTOR THEORY OF ATHEROGENESIS
The evidence on the role of Toll-like receptors (TLR) and their ligands in atherosclerosis development has been summarised. Bacterial lipopolysaccharides (LPS) could interact with TLR4 and induce macrophage transformation into foam cells, triggering atherosclerotic lesion development in the vascular...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2010-04-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1445 |
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| author | V. G. Likhoded V. M. Bondarenko A. L. Gintzburg |
| author_facet | V. G. Likhoded V. M. Bondarenko A. L. Gintzburg |
| author_sort | V. G. Likhoded |
| collection | DOAJ |
| description | The evidence on the role of Toll-like receptors (TLR) and their ligands in atherosclerosis development has been summarised. Bacterial lipopolysaccharides (LPS) could interact with TLR4 and induce macrophage transformation into foam cells, triggering atherosclerotic lesion development in the vascular wall. TLR4 mutations are associated with reduced atherosclerosis risk. Other microbial ligands and heat shock proteins could also induce atherosclerosis. A universal theory of atherogenesis is proposed, considering atherosclerosis induction and progression as an adverse effect of the interaction between exogenous and endogenous ligands and TLR. |
| format | Article |
| id | doaj-art-af804acf32384219be4fa7fb8d98b4b6 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2010-04-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-af804acf32384219be4fa7fb8d98b4b62025-08-20T03:00:22Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202010-04-010292961233EXOGENOUS AND ENDOGENOUS FACTORS IN ATHEROSCLEROSIS PATHOGENESIS. RECEPTOR THEORY OF ATHEROGENESISV. G. Likhoded0V. M. Bondarenko1A. L. Gintzburg2НИИ эпидемиологии и микробиологии им.Н.Ф.Гамалеи РАМН, МоскваНИИ эпидемиологии и микробиологии им.Н.Ф.Гамалеи РАМН, МоскваНИИ эпидемиологии и микробиологии им.Н.Ф.Гамалеи РАМН, МоскваThe evidence on the role of Toll-like receptors (TLR) and their ligands in atherosclerosis development has been summarised. Bacterial lipopolysaccharides (LPS) could interact with TLR4 and induce macrophage transformation into foam cells, triggering atherosclerotic lesion development in the vascular wall. TLR4 mutations are associated with reduced atherosclerosis risk. Other microbial ligands and heat shock proteins could also induce atherosclerosis. A universal theory of atherogenesis is proposed, considering atherosclerosis induction and progression as an adverse effect of the interaction between exogenous and endogenous ligands and TLR.https://russjcardiol.elpub.ru/jour/article/view/1445toll-like receptors (tlr)lipopolysaccharides (lps)tlr ligandsatherogenesis |
| spellingShingle | V. G. Likhoded V. M. Bondarenko A. L. Gintzburg EXOGENOUS AND ENDOGENOUS FACTORS IN ATHEROSCLEROSIS PATHOGENESIS. RECEPTOR THEORY OF ATHEROGENESIS Российский кардиологический журнал toll-like receptors (tlr) lipopolysaccharides (lps) tlr ligands atherogenesis |
| title | EXOGENOUS AND ENDOGENOUS FACTORS IN ATHEROSCLEROSIS PATHOGENESIS. RECEPTOR THEORY OF ATHEROGENESIS |
| title_full | EXOGENOUS AND ENDOGENOUS FACTORS IN ATHEROSCLEROSIS PATHOGENESIS. RECEPTOR THEORY OF ATHEROGENESIS |
| title_fullStr | EXOGENOUS AND ENDOGENOUS FACTORS IN ATHEROSCLEROSIS PATHOGENESIS. RECEPTOR THEORY OF ATHEROGENESIS |
| title_full_unstemmed | EXOGENOUS AND ENDOGENOUS FACTORS IN ATHEROSCLEROSIS PATHOGENESIS. RECEPTOR THEORY OF ATHEROGENESIS |
| title_short | EXOGENOUS AND ENDOGENOUS FACTORS IN ATHEROSCLEROSIS PATHOGENESIS. RECEPTOR THEORY OF ATHEROGENESIS |
| title_sort | exogenous and endogenous factors in atherosclerosis pathogenesis receptor theory of atherogenesis |
| topic | toll-like receptors (tlr) lipopolysaccharides (lps) tlr ligands atherogenesis |
| url | https://russjcardiol.elpub.ru/jour/article/view/1445 |
| work_keys_str_mv | AT vglikhoded exogenousandendogenousfactorsinatherosclerosispathogenesisreceptortheoryofatherogenesis AT vmbondarenko exogenousandendogenousfactorsinatherosclerosispathogenesisreceptortheoryofatherogenesis AT algintzburg exogenousandendogenousfactorsinatherosclerosispathogenesisreceptortheoryofatherogenesis |