Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection
Infections by the pathogenic yeasts Candida albicans and Candida glabrata are among the most common fungal diseases. The success of these species as human pathogens is contingent on their ability to resist antifungal therapy and thrive within the human host. C. glabrata is especially resilient to az...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2019-02-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/2019a-pais-microbial-cell/ |
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| author | Pedro Pais Mónica Galocha Romeu Viana Mafalda Cavalheiro Diana Pereira Miguel Cacho Teixeira |
| author_facet | Pedro Pais Mónica Galocha Romeu Viana Mafalda Cavalheiro Diana Pereira Miguel Cacho Teixeira |
| author_sort | Pedro Pais |
| collection | DOAJ |
| description | Infections by the pathogenic yeasts Candida albicans and Candida glabrata are among the most common fungal diseases. The success of these species as human pathogens is contingent on their ability to resist antifungal therapy and thrive within the human host. C. glabrata is especially resilient to azole antifungal treatment, while C. albicans is best known for its wide array of virulence features. The core mechanisms that underlie antifungal resistance and virulence in these pathogens has been continuously addressed, but the investigation on how such mechanisms evolve according to each environment is scarcer. This review aims to explore current knowledge on microevolution experiments to several treatment and host-associated conditions in C. albicans and C. glabrata. The analysis of adaptation strategies that evolve over time will allow to better understand the mechanisms by which Candida species are able to achieve stable phenotypes in real-life scenarios, which are the ones that should constitute the most interesting drug targets. |
| format | Article |
| id | doaj-art-af7d65d4d9f54ffb9a6cc0e2c5b48a05 |
| institution | DOAJ |
| issn | 2311-2638 |
| language | English |
| publishDate | 2019-02-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-af7d65d4d9f54ffb9a6cc0e2c5b48a052025-08-20T02:57:39ZengShared Science Publishers OGMicrobial Cell2311-26382019-02-016314215910.15698/mic2019.03.670Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infectionPedro Pais0Mónica Galocha1Romeu Viana2Mafalda Cavalheiro3Diana Pereira4Miguel Cacho Teixeira5Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.Infections by the pathogenic yeasts Candida albicans and Candida glabrata are among the most common fungal diseases. The success of these species as human pathogens is contingent on their ability to resist antifungal therapy and thrive within the human host. C. glabrata is especially resilient to azole antifungal treatment, while C. albicans is best known for its wide array of virulence features. The core mechanisms that underlie antifungal resistance and virulence in these pathogens has been continuously addressed, but the investigation on how such mechanisms evolve according to each environment is scarcer. This review aims to explore current knowledge on microevolution experiments to several treatment and host-associated conditions in C. albicans and C. glabrata. The analysis of adaptation strategies that evolve over time will allow to better understand the mechanisms by which Candida species are able to achieve stable phenotypes in real-life scenarios, which are the ones that should constitute the most interesting drug targets.http://microbialcell.com/researcharticles/2019a-pais-microbial-cell/fungal pathogenshost-pathogen interactionmicroevolutionvirulencebiofilm formationantifungal resistance |
| spellingShingle | Pedro Pais Mónica Galocha Romeu Viana Mafalda Cavalheiro Diana Pereira Miguel Cacho Teixeira Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection Microbial Cell fungal pathogens host-pathogen interaction microevolution virulence biofilm formation antifungal resistance |
| title | Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection |
| title_full | Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection |
| title_fullStr | Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection |
| title_full_unstemmed | Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection |
| title_short | Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection |
| title_sort | microevolution of the pathogenic yeasts candida albicans and candida glabrata during antifungal therapy and host infection |
| topic | fungal pathogens host-pathogen interaction microevolution virulence biofilm formation antifungal resistance |
| url | http://microbialcell.com/researcharticles/2019a-pais-microbial-cell/ |
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