Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro‐inflammatory in labor

Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro‐inflammatory in labor

Abstract The shift of cytokine profile from anti‐ to pro‐inflammatory is the most recognizable sign of labor, although the underlying mechanism remains elusive. Here, we report that the epithelial sodium channel (ENaC) is upregulated and activated in the uterus at labor in mice. Mechanical activatio...

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Bibliographic Details
Main Authors: Xiao Sun, Jing Hui Guo, Dan Zhang, Jun‐jiang Chen, Wei Yin Lin, Yun Huang, Hui Chen, Wen Qing Huang, Yifeng Liu, Lai Ling Tsang, Mei Kuen Yu, Yiu Wa Chung, Xiaohua Jiang, Hefeng Huang, Hsiao Chang Chan, Ye Chun Ruan
Format: Article
Language:English
Published: Springer Nature 2018-08-01
Series:EMBO Molecular Medicine
Subjects:
ENaC
labor/parturition
preterm labor
pro‐inflammatory
Online Access:https://doi.org/10.15252/emmm.201808868
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https://doi.org/10.15252/emmm.201808868

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