Integration of continuous lumbar drainage and third-generation EGFR-TKI in managing leptomeningeal metastasis-induced life-threatening intracranial hypertension: a case report

Integration of continuous lumbar drainage and third-generation EGFR-TKI in managing leptomeningeal metastasis-induced life-threatening intracranial hypertension: a case report

Leptomeningeal metastasis (LM) from lung cancer carries an extremely poor prognosis, with patients often presenting severe intracranial hypertension symptoms such as intractable headache and recurrent vomiting. Ventriculoperitoneal (VP) shunt placement is commonly used to manage intracranial hyperte...

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Bibliographic Details
Main Authors: Lei Wang, Nianjun Ren, Zhi Tang, Rui Wang, Zhengwen He
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
leptomeningeal metastasis
lumbar drainage
third-generation EGFR-TKI
NSCLC
intracranial hypertension
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1581754/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1581754/full

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