Nuclear PKM2: a signal receiver, a gene programmer, and a metabolic modulator

Nuclear PKM2: a signal receiver, a gene programmer, and a metabolic modulator

Abstract Pyruvate kinase M2 (PKM2) is a key enzyme involved in glycolysis, yet its role in cancer extends far beyond metabolic flux. Unlike its isoform PKM1, PKM2 exhibits unique regulatory properties due to alternative splicing and dynamic structural plasticity, enabling it to translocate into the...

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Bibliographic Details
Main Authors: Tsan-Jan Chen, Chun-Hsien Wu, Mien-Chie Hung, Wen-Ching Wang, Hsing-Jien Kung
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Biomedical Science
Subjects:
Nuclear PKM2
Nuclear translocation
Post-translational modification
Oncogenic signaling
Cancer metabolism
Signal receiver
Online Access:https://doi.org/10.1186/s12929-025-01170-6
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https://doi.org/10.1186/s12929-025-01170-6

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