Efficacy and safety of trastuzumab deruxtecan in gastrointestinal malignancies: a systemic review and meta-analysis

Efficacy and safety of trastuzumab deruxtecan in gastrointestinal malignancies: a systemic review and meta-analysis

BackgroundTrastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) that is effective in treating gastrointestinal (GI) cancers. However, the significant variability in its reported efficacy and safety profiles is likely due to differences in trial designs, patient populations, and clinical...

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Main Authors: Ali Hussain, Qamar Iqbal, Sangeetha Isaac, Faisal Shariff, Ezza Tariq, Hassan Awais, Nayan Mainkar, Heidi Lynn Reis, Aakriti Arora, Akshay Deotare, Azka Tasleem, Srijan Valasapalli, Munizay Paracha, Maya Hashmi, Hamdi Battah, Mahvish Muzaffar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Gastroenterology
Subjects:
trastuzumab deruxtecan (T-DXd)
antibody-drug conjugate (ADC)
gastrointestinal malignancies
safety
efficacy
HER2-positive
Online Access:https://www.frontiersin.org/articles/10.3389/fgstr.2025.1559934/full
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https://www.frontiersin.org/articles/10.3389/fgstr.2025.1559934/full

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