Concurrent treatment with transarterial immunoembolization of hepatic metastases and systemic immune checkpoint inhibitors to overcome immune evasion in patients with metastatic uveal melanoma

Concurrent treatment with transarterial immunoembolization of hepatic metastases and systemic immune checkpoint inhibitors to overcome immune evasion in patients with metastatic uveal melanoma

Abstract Background Metastatic uveal melanoma (mUM) is an uncommon melanoma subtype, poorly immunogenic with low objective response rates (ORR) to immune checkpoint inhibitors (ICI). Liver-directed therapies (LDT) are commonly used given the strong predilection for hepatic metastases. Transarterial...

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Bibliographic Details
Main Authors: Natalie J. Miller, Sharon W. Kwan, Jacob B. Leary, Daniel S. Hippe, William McCamy, Joshua R. Veatch, Evan T. Hall, Wayne L. Monsky, Shailender Bhatia
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Uveal melanoma
Choroidal melanoma
Immunoembolization
GM-CSF
Checkpoint blockade
Online Access:https://doi.org/10.1007/s00262-025-04124-x
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https://doi.org/10.1007/s00262-025-04124-x

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