Pulsed stimuli enable p53 phase resetting to synchronize single cells and modulate cell fate

Pulsed stimuli enable p53 phase resetting to synchronize single cells and modulate cell fate

Abstract Oscillatory p53 expression occurs in individual cells responding to DNA breaks. While the majority of cells exhibit the same qualitative response, quantitative features of the oscillations (e.g., amplitude or period) can be highly variable between cells, generating heterogeneity in downstre...

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Bibliographic Details
Main Authors: Harish Venkatachalapathy, Samuel Dallon, Zhilin Yang, Samira M Azarin, Casim A Sarkar, Eric Batchelor
Format: Article
Language:English
Published: Springer Nature 2025-03-01
Series:Molecular Systems Biology
Subjects:
p53
Oscillations
Single-cell Heterogeneity
Dynamical Systems
Phase Resetting
Online Access:https://doi.org/10.1038/s44320-025-00091-8
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https://doi.org/10.1038/s44320-025-00091-8

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