LDH and glycolytic activity as predictors of immunotherapy response in gastric cancer: a systematic review and meta-analysis

LDH and glycolytic activity as predictors of immunotherapy response in gastric cancer: a systematic review and meta-analysis

BackgroundImmune checkpoint inhibitors (ICIs) have transformed gastric cancer (GC) treatment, but response heterogeneity necessitates reliable prognostic biomarkers. This meta-analysis investigates the predictive value of metabolic (LDH, glycolytic activity) and inflammatory markers (NLR, PLR, LMR)...

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Bibliographic Details
Main Authors: Li Zhu, Juanjuan Ruan, Qing Zhang, Li Feng, Ying Deng, Lili Dai, Yuanyuan Zheng, Zhijuan Feng, Ruihan Xu, Keqin Liu, Nan Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
gastric cancer
immunotherapy
lactate dehydrogenase
neutrophil-lymphocyte ratio
prognostic biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605976/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605976/full

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