Multi-omics analysis of diabetic cardiomyopathy pathogenesis using a type 2 diabetic Zucker diabetic fatty rat model

Multi-omics analysis of diabetic cardiomyopathy pathogenesis using a type 2 diabetic Zucker diabetic fatty rat model

Abstract Diabetic cardiomyopathy (DCM) is a leading cause of mortality in patients with diabetes, highlighting the need to better understand its mechanisms for effective treatment. The primary pathogenic mechanism of DCM is mitochondrial dysfunction associated with increased oxidative stress; howeve...

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Main Authors: Kazuhiro Tanabe, Qianqian Zheng, Xuguang Zhang, Naoki Tanaka, Chihiro Hayashi, Asaka Yokota, Rina Otsuka, Tomoko Katahira, Motoyuki Kohjima, Makoto Nakamuta
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Diabetic cardiomyopathy
Mitochondrial disfunction
Oxidative stress
Metabolomics
Proteomics
ROS
Online Access:https://doi.org/10.1038/s41598-025-04670-5
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https://doi.org/10.1038/s41598-025-04670-5

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