Shikonin inhibits NLRP3 inflammasome activation and controls inflammatory disease

Shikonin inhibits NLRP3 inflammasome activation and controls inflammatory disease

Abstract Shikonin (SHK) is a plant-derived naphthoquinone known for its anti-inflammatory activity, though the mechanism remains largely unexplored. The NLRP3 inflammasome, one of the most studied inflammasomes, can cause uncontrolled inflammation and drive various diseases when dysregulated. Here,...

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Bibliographic Details
Main Authors: Jing Huang, Mengmeng Dai, Xinyu Huang, Wenqing Qi, Jing Jing, Jiayi He, Zhizhuo Lu, Chaofang Zhang, Guiling Wang, Run Cao, Yuanfang Ma, Hailong Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
NLRP3inflammasome
SHK
ROS
ox-mtDNA
Inflammatory diseases
Online Access:https://doi.org/10.1038/s41598-025-03512-8
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https://doi.org/10.1038/s41598-025-03512-8

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