Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities
Three unknown impurities in rosiglitazone maleate 1 bulk drug at level below 0.1% (ranging from 0.05 to 0.1%) were detected by simple reverse phase high performance liquid chromatography. These impurities were preliminarily identified with LC-MS and characterized by the mass number of the impurities...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/308724 |
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| author | Singamsetty Radha Krishna Mandava Venkata Naga Brahmeshwar Rao Tirmalaraju Satyanaryana Raju Vurimidi Himabindu Ghanta Mahesh Reddy |
| author_facet | Singamsetty Radha Krishna Mandava Venkata Naga Brahmeshwar Rao Tirmalaraju Satyanaryana Raju Vurimidi Himabindu Ghanta Mahesh Reddy |
| author_sort | Singamsetty Radha Krishna |
| collection | DOAJ |
| description | Three unknown impurities in rosiglitazone maleate 1 bulk drug at level below 0.1% (ranging from 0.05 to 0.1%) were detected by simple reverse phase high performance liquid chromatography. These impurities were preliminarily identified with LC-MS and characterized by the mass number of the impurities. Different experiments were conducted and finally synthesized and characterized the unknown impurities. |
| format | Article |
| id | doaj-art-af1455d7da884e00915916dfc7179ed6 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-af1455d7da884e00915916dfc7179ed62025-02-03T06:05:10ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-015356256610.1155/2008/308724Isolation, Synthesis and Characterization of Rosiglitazone Maleate ImpuritiesSingamsetty Radha Krishna0Mandava Venkata Naga Brahmeshwar Rao1Tirmalaraju Satyanaryana Raju2Vurimidi Himabindu3Ghanta Mahesh Reddy4Research and Development, Dr. Reddy's Laboratories Ltd., Integrated Product and Development, Unit-III, Plot No. 116, S V Co-Op. Ind. Estate, Bollaram, Jinnaram, Medak Dist 502 325; A P, IndiaResearch and Development, Dr. Reddy's Laboratories Ltd., Integrated Product and Development, Unit-III, Plot No. 116, S V Co-Op. Ind. Estate, Bollaram, Jinnaram, Medak Dist 502 325; A P, IndiaResearch and Development, Dr. Reddy's Laboratories Ltd., Integrated Product and Development, Unit-III, Plot No. 116, S V Co-Op. Ind. Estate, Bollaram, Jinnaram, Medak Dist 502 325; A P, IndiaInstitute of Sciences and Technology, Center for Environmental Sciences, J.N.T. University, Kukatpally, Hyderabad-500072, IndiaResearch and Development, Dr. Reddy's Laboratories Ltd., Integrated Product and Development, Unit-III, Plot No. 116, S V Co-Op. Ind. Estate, Bollaram, Jinnaram, Medak Dist 502 325; A P, IndiaThree unknown impurities in rosiglitazone maleate 1 bulk drug at level below 0.1% (ranging from 0.05 to 0.1%) were detected by simple reverse phase high performance liquid chromatography. These impurities were preliminarily identified with LC-MS and characterized by the mass number of the impurities. Different experiments were conducted and finally synthesized and characterized the unknown impurities.http://dx.doi.org/10.1155/2008/308724 |
| spellingShingle | Singamsetty Radha Krishna Mandava Venkata Naga Brahmeshwar Rao Tirmalaraju Satyanaryana Raju Vurimidi Himabindu Ghanta Mahesh Reddy Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities E-Journal of Chemistry |
| title | Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities |
| title_full | Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities |
| title_fullStr | Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities |
| title_full_unstemmed | Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities |
| title_short | Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities |
| title_sort | isolation synthesis and characterization of rosiglitazone maleate impurities |
| url | http://dx.doi.org/10.1155/2008/308724 |
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