Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities

Three unknown impurities in rosiglitazone maleate 1 bulk drug at level below 0.1% (ranging from 0.05 to 0.1%) were detected by simple reverse phase high performance liquid chromatography. These impurities were preliminarily identified with LC-MS and characterized by the mass number of the impurities...

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Bibliographic Details
Main Authors: Singamsetty Radha Krishna, Mandava Venkata Naga Brahmeshwar Rao, Tirmalaraju Satyanaryana Raju, Vurimidi Himabindu, Ghanta Mahesh Reddy
Format: Article
Language:English
Published: Wiley 2008-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2008/308724
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