Safety and tolerability of metformin in overweight and obese patients with dengue: An open-label clinical trial (MeDO).

Safety and tolerability of metformin in overweight and obese patients with dengue: An open-label clinical trial (MeDO).

<h4>Background</h4>Despite dengue being a major public health problem, there are no antiviral or adjunctive treatments for the disease. Novel therapeutics are needed, particularly for patients at high risk of severe disease, including those living with obesity. Metformin reduces dengue v...

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Main Authors: Nguyet Minh Nguyen, Dong Thi Hoai Tam, Ho Quang Chanh, Huynh Trung Trieu, Nguyen Thi Xuan Chau, Nguyen Thanh Van, Nguyen Thanh Phong, Cao Thi Tam, Nguyen Thi Hong Lan, Luong Thi Hue Tai, Nguyen Thi Cam Huong, Le Thi Ngoc Thuan, Nguyen Van Hao, Phan Tu Qui, Tran Thi Dong Vien, Pham Thi Hai Men, Huynh Thi Thuy Hoa, Phan Vinh Tho, Huynh Thi Le Duyen, Vi Tran Thuy, Thuan Dang Trong, Nguyen Tan Thanh Kieu, Angela McBride, Evelyne Kestelyn, Ronald B Geskus, Nguyen Lam Vuong, Sophie Yacoub
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0013281
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https://doi.org/10.1371/journal.pntd.0013281

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