An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour

Abstract Cortical layer 6 neurons are the only projection neuron population in the cortical mantle known to electrophysiologically respond to orexin—a neuropeptide involved in cortical arousal and emotive behaviour. These neurons exhibit extensive intercortical and thalamic projections, yet the exac...

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Main Authors: Fernando Messore, Rajeevan Narayanan Therpurakal, Jean-Philippe Dufour, Anna Hoerder-Suabedissen, Luiz Guidi, Kim Korrell, Marissa Mueller, Mohammed Abuelem, Armin Lak, David M. Bannerman, Edward O. Mann, Zoltán Molnár
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03350-2
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