The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect of Artemisia judaica L. Essential Oil
Artemisia judaica L. is a medicinal plant that is traditionally used to relieve abdominal pains through its carminative activity. In this study, spectroscopic analysis was employed to investigate the carminative activity associated with A. judaica. Using infrared spectroscopy, the carminative activi...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2014/627038 |
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| author | Muhammed Alzweiri Ibrahim M. Alrawashdeh Sanaa K. Bardaweel |
| author_facet | Muhammed Alzweiri Ibrahim M. Alrawashdeh Sanaa K. Bardaweel |
| author_sort | Muhammed Alzweiri |
| collection | DOAJ |
| description | Artemisia judaica L. is a medicinal plant that is traditionally used to relieve abdominal pains through its carminative activity. In this study, spectroscopic analysis was employed to investigate the carminative activity associated with A. judaica. Using infrared spectroscopy, the carminative activity was evaluated based on the first derivative of IR-characteristic stretching signal of CO2. Our results indicate that A. judaica oil effectively reduced the response of CO2 signal equivalent to thymol standard. Additionally, 1H-NMR spectroscopy was utilized to assess surface activity of A. judaica crude oil through the reduction of interfacial tension in a D2O/CDCl3 system. Apparently, 10 mg of the oil was able to solubilize water in a chloroform layer up to 4.3% (w/w). In order to correlate the observed surface activity of the oil to its actual composition, GC-MS and GC-FID structural analysis were undertaken. The results revealed that the oil composition consists of oxygenated terpenes which might be responsible for the carminative effect. Furthermore, owing to its sensitivity, our model provides a fundamental basis for the pharmacological assessment of trace amounts of oils with high precision and accuracy. |
| format | Article |
| id | doaj-art-aed25c4ae15e47b1bc8619b6cbf952f1 |
| institution | Kabale University |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-aed25c4ae15e47b1bc8619b6cbf952f12025-02-03T01:27:27ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792014-01-01201410.1155/2014/627038627038The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect of Artemisia judaica L. Essential OilMuhammed Alzweiri0Ibrahim M. Alrawashdeh1Sanaa K. Bardaweel2Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942, JordanDepartment of Biological Sciences, Faculty of Sciences, Al-Hussein Bin Talal University, Ma’an 20, JordanDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942, JordanArtemisia judaica L. is a medicinal plant that is traditionally used to relieve abdominal pains through its carminative activity. In this study, spectroscopic analysis was employed to investigate the carminative activity associated with A. judaica. Using infrared spectroscopy, the carminative activity was evaluated based on the first derivative of IR-characteristic stretching signal of CO2. Our results indicate that A. judaica oil effectively reduced the response of CO2 signal equivalent to thymol standard. Additionally, 1H-NMR spectroscopy was utilized to assess surface activity of A. judaica crude oil through the reduction of interfacial tension in a D2O/CDCl3 system. Apparently, 10 mg of the oil was able to solubilize water in a chloroform layer up to 4.3% (w/w). In order to correlate the observed surface activity of the oil to its actual composition, GC-MS and GC-FID structural analysis were undertaken. The results revealed that the oil composition consists of oxygenated terpenes which might be responsible for the carminative effect. Furthermore, owing to its sensitivity, our model provides a fundamental basis for the pharmacological assessment of trace amounts of oils with high precision and accuracy.http://dx.doi.org/10.1155/2014/627038 |
| spellingShingle | Muhammed Alzweiri Ibrahim M. Alrawashdeh Sanaa K. Bardaweel The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect of Artemisia judaica L. Essential Oil International Journal of Analytical Chemistry |
| title | The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect of Artemisia judaica L. Essential Oil |
| title_full | The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect of Artemisia judaica L. Essential Oil |
| title_fullStr | The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect of Artemisia judaica L. Essential Oil |
| title_full_unstemmed | The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect of Artemisia judaica L. Essential Oil |
| title_short | The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect of Artemisia judaica L. Essential Oil |
| title_sort | development and application of novel ir and nmr based model for the evaluation of carminative effect of artemisia judaica l essential oil |
| url | http://dx.doi.org/10.1155/2014/627038 |
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