Causal association of immune-related genes with mouth ulcers: findings from summary-based Mendelian randomization and transcriptome-wide association analysis

Causal association of immune-related genes with mouth ulcers: findings from summary-based Mendelian randomization and transcriptome-wide association analysis

Oral ulceration is the most common ulcerative condition in humans, yet its underlying etiology remains poorly understood. To identify potential causal genes involved in the pathogenesis of mouth ulcers, we applied summary data-based Mendelian randomization (SMR) using eQTL data from GTEx and CAGE, a...

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Bibliographic Details
Main Authors: Mengru Shi, Tianqi Wang, Qi Xie, Guangwei Yuan, Juan Xia, Jingyun Yang, Weili Xie, Zetao Chen, Xiaobing Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2025-05-01
Series:Immunological Medicine
Subjects:
Mouth ulcers
expression quantitative trait loci
summary Mendelian randomization
genome-wide association study
transcriptome-wide association analysis
Online Access:https://www.tandfonline.com/doi/10.1080/25785826.2025.2498106
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https://www.tandfonline.com/doi/10.1080/25785826.2025.2498106

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