Myxoma virus lacking the host range determinant M062 stimulates cGAS-dependent type 1 interferon response and unique transcriptomic changes in human monocytes/macrophages.

Myxoma virus lacking the host range determinant M062 stimulates cGAS-dependent type 1 interferon response and unique transcriptomic changes in human monocytes/macrophages.

The evolutionarily successful poxviruses possess effective and diverse strategies to circumvent or overcome host defense mechanisms. Poxviruses encode many immunoregulatory proteins to evade host immunity to establish a productive infection and have unique means of inhibiting DNA sensing-dependent t...

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Main Authors: Steven J Conrad, Tahseen Raza, Erich A Peterson, Jason Liem, Richard Connor, Bernice Nounamo, Martin Cannon, Jia Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-09-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010316&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010316&type=printable

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