Protective effects of dill fruit against acute acetic acid‐induced ulcerative colitis by reducing inflammation and oxidative stress in rats
Abstract Nutritherapy is the art of using nutrients as a means of preventing or correcting dysfunction in the body. We aimed to evaluate the protective effect of dill fruit aqueous extract (DFAE) against acetic acid‐induced ulcerative colitis. Healthy male rats (N = 42) were divided into seven group...
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Wiley
2025-05-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70393 |
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| author | Chirine Brinsi Yassin Khadraoui Mariem Mhimdi Slimen Selmi Houcem Sammari Saber Jedidi Houcine Selmi Hichem Sebai |
| author_facet | Chirine Brinsi Yassin Khadraoui Mariem Mhimdi Slimen Selmi Houcem Sammari Saber Jedidi Houcine Selmi Hichem Sebai |
| author_sort | Chirine Brinsi |
| collection | DOAJ |
| description | Abstract Nutritherapy is the art of using nutrients as a means of preventing or correcting dysfunction in the body. We aimed to evaluate the protective effect of dill fruit aqueous extract (DFAE) against acetic acid‐induced ulcerative colitis. Healthy male rats (N = 42) were divided into seven groups of six animals each, with groups 1 and 2 being controls, groups 3, 4, and 5 given increasing doses of DFAE (50, 100, and 200 mg/kg, b.w., p.o.), and groups 6 and 7 were given sulfasalazine (100 mg/kg, b.w., p.o.) and gallic acid (50 mg/kg, b.w., p.o.), respectively, during 10 days. In vitro, we found that DFAE's IC50 exhibited a significant antioxidant capacity due to its high phenolic content. The in vivo studies showed that the pre‐treatment with DFAE significantly reduced AA‐induced morphological and histopathological alterations of the colonic mucosa. The antioxidant and anti‐inflammatory power of DFAE maintained the redox equilibrium and preserved the intracellular mediators' homeostasis. Our data may suggest that dill fruit is a promising candidate for treating ulcerative colitis by controlling oxidative stress and inflammation. |
| format | Article |
| id | doaj-art-aea8b7dfd8a74713b8ebc14f38b41800 |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-aea8b7dfd8a74713b8ebc14f38b418002025-08-20T04:27:55ZengWileyPhysiological Reports2051-817X2025-05-011310n/an/a10.14814/phy2.70393Protective effects of dill fruit against acute acetic acid‐induced ulcerative colitis by reducing inflammation and oxidative stress in ratsChirine Brinsi0Yassin Khadraoui1Mariem Mhimdi2Slimen Selmi3Houcem Sammari4Saber Jedidi5Houcine Selmi6Hichem Sebai7Laboratory of Functional Physiology and Valorization of Bio‐Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of Béja Béja TunisiaLaboratory of Functional Physiology and Valorization of Bio‐Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of Béja Béja TunisiaLaboratory of Functional Physiology and Valorization of Bio‐Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of Béja Béja TunisiaLaboratory of Functional Physiology and Valorization of Bio‐Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of Béja Béja TunisiaLaboratory of Functional Physiology and Valorization of Bio‐Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of Béja Béja TunisiaLaboratory of Functional Physiology and Valorization of Bio‐Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of Béja Béja TunisiaLaboratory of Sylvo‐Pastoral Resources University of Jendouba, Institution of Agricultural Research and Higher Education (IRESA), Sylvo‐Pastoral Institute of Tabarka Tabarka TunisiaLaboratory of Functional Physiology and Valorization of Bio‐Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of Béja Béja TunisiaAbstract Nutritherapy is the art of using nutrients as a means of preventing or correcting dysfunction in the body. We aimed to evaluate the protective effect of dill fruit aqueous extract (DFAE) against acetic acid‐induced ulcerative colitis. Healthy male rats (N = 42) were divided into seven groups of six animals each, with groups 1 and 2 being controls, groups 3, 4, and 5 given increasing doses of DFAE (50, 100, and 200 mg/kg, b.w., p.o.), and groups 6 and 7 were given sulfasalazine (100 mg/kg, b.w., p.o.) and gallic acid (50 mg/kg, b.w., p.o.), respectively, during 10 days. In vitro, we found that DFAE's IC50 exhibited a significant antioxidant capacity due to its high phenolic content. The in vivo studies showed that the pre‐treatment with DFAE significantly reduced AA‐induced morphological and histopathological alterations of the colonic mucosa. The antioxidant and anti‐inflammatory power of DFAE maintained the redox equilibrium and preserved the intracellular mediators' homeostasis. Our data may suggest that dill fruit is a promising candidate for treating ulcerative colitis by controlling oxidative stress and inflammation.https://doi.org/10.14814/phy2.70393Anethum graveolens L.inflammationoxidative stressratsulcerative colitis |
| spellingShingle | Chirine Brinsi Yassin Khadraoui Mariem Mhimdi Slimen Selmi Houcem Sammari Saber Jedidi Houcine Selmi Hichem Sebai Protective effects of dill fruit against acute acetic acid‐induced ulcerative colitis by reducing inflammation and oxidative stress in rats Physiological Reports Anethum graveolens L. inflammation oxidative stress rats ulcerative colitis |
| title | Protective effects of dill fruit against acute acetic acid‐induced ulcerative colitis by reducing inflammation and oxidative stress in rats |
| title_full | Protective effects of dill fruit against acute acetic acid‐induced ulcerative colitis by reducing inflammation and oxidative stress in rats |
| title_fullStr | Protective effects of dill fruit against acute acetic acid‐induced ulcerative colitis by reducing inflammation and oxidative stress in rats |
| title_full_unstemmed | Protective effects of dill fruit against acute acetic acid‐induced ulcerative colitis by reducing inflammation and oxidative stress in rats |
| title_short | Protective effects of dill fruit against acute acetic acid‐induced ulcerative colitis by reducing inflammation and oxidative stress in rats |
| title_sort | protective effects of dill fruit against acute acetic acid induced ulcerative colitis by reducing inflammation and oxidative stress in rats |
| topic | Anethum graveolens L. inflammation oxidative stress rats ulcerative colitis |
| url | https://doi.org/10.14814/phy2.70393 |
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