Tracking HIV persistence across T cell lineages during early ART-treated HIV-1-infection using a reservoir-marking humanized mouse model

Tracking HIV persistence across T cell lineages during early ART-treated HIV-1-infection using a reservoir-marking humanized mouse model

Abstract Human immunodeficiency virus (HIV) infection depletes CD4 T-cells, and long-term persistence of latent virus prevents full clearance of HIV even in the presence of effective antiretroviral therapy (ART), Here we present the HIV-1-induced lineage tracing (HILT) system, a model that irreversi...

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Main Authors: Namita Satija, Foramben Patel, Gerrit Schmidt, Donald V. Doanman, Manav Kapoor, Annalena La Porte, Ying-Chih Wang, Kenneth M. Law, Anthony M. Esposito, Kimaada Allette, Kristin G. Beaumont, Robert P. Sebra, Benjamin K. Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57368-7
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https://doi.org/10.1038/s41467-025-57368-7

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