Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice.

Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice.

Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to investigate the potential o...

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Main Authors: Raphaël Weibel, David Reiss, Laurie Karchewski, Olivier Gardon, Audrey Matifas, Dominique Filliol, Jérôme A J Becker, John N Wood, Brigitte L Kieffer, Claire Gaveriaux-Ruff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0074706
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https://doi.org/10.1371/journal.pone.0074706

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