Development and Optimization of a Redox Enzyme-Based Fluorescence Biosensor for the Identification of MsrB1 Inhibitors

Development and Optimization of a Redox Enzyme-Based Fluorescence Biosensor for the Identification of MsrB1 Inhibitors

MsrB1 is a thiol-dependent enzyme that reduces protein methionine-<i>R</i>-sulfoxide and regulates inflammatory response in macrophages. Therefore, MsrB1 could be a promising therapeutic target for the control of inflammation. To identify MsrB1 inhibitors, we construct a redox protein-ba...

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Main Authors: Hyun Bo Shim, Hyunjeong Lee, Hwa Yeon Cho, Young Ho Jo, Lionel Tarrago, Hyunggee Kim, Vadim N. Gladyshev, Byung Cheon Lee
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Antioxidants
Subjects:
methionine sulfoxide reductase B1
redox protein-based fluorescence biosensor
high-throughput screening
inhibitor
inflammation
circularly permuted yellow fluorescence protein
Online Access:https://www.mdpi.com/2076-3921/13/11/1348
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https://www.mdpi.com/2076-3921/13/11/1348

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