Bank1 deficiency reshapes the gut microbiota of lupus mice towards an anti-inflammatory composition

Bank1 deficiency reshapes the gut microbiota of lupus mice towards an anti-inflammatory composition

The B-cell scaffold protein with ankyrin repeats (BANK1) regulates Toll-like receptor-7 (TLR7) signaling in B cells and its absence ameliorates lupus. Here, we investigated the involvement of Bank1 in the gut mucosal B cell response to commensals in a murine model of lupus. In health and disease, Ba...

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Main Authors: Georgina Galicia, María Botía-Sánchez, Daniel Toro-Dominguez, Ana López García, Juan Rafael Valera, Gonzalo Gómez Hernández, Raquel Marcos Fernandez, Noelia Carmona, Gracia Luque, María Morell, Nieves Varela, Francisco Pérez-Cozar, Abelardo Margolles, Margarita Aguilera, Marta E. Alarcón-Riquelme
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
microbiota
IgA
systemic lupus erythematosus (SLE)
TLR7
BANK1
genetics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586025/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586025/full

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