RNA polymerase II primes Polycomb‐repressed developmental genes throughout terminal neuronal differentiation

RNA polymerase II primes Polycomb‐repressed developmental genes throughout terminal neuronal differentiation

Abstract Polycomb repression in mouse embryonic stem cells (ESCs) is tightly associated with promoter co‐occupancy of RNA polymerase II (RNAPII) which is thought to prime genes for activation during early development. However, it is unknown whether RNAPII poising is a general feature of Polycomb rep...

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Main Authors: Carmelo Ferrai, Elena Torlai Triglia, Jessica R Risner‐Janiczek, Tiago Rito, Owen JL Rackham, Inês de Santiago, Alexander Kukalev, Mario Nicodemi, Altuna Akalin, Meng Li, Mark A Ungless, Ana Pombo
Format: Article
Language:English
Published: Springer Nature 2017-10-01
Series:Molecular Systems Biology
Subjects:
cell plasticity
chromatin bivalency
gene regulation
RNA polymerase II
transcriptional poising
Online Access:https://doi.org/10.15252/msb.20177754
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https://doi.org/10.15252/msb.20177754

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